The Forms and Fractions of Lion’s Mane - Part 2
Lion's Mane benefits depend on how it’s extracted. Discover why dual extraction methods unlock more cognitive and hormonal benefits.
Reid Parr
Reid Parr | WBN News – Vancouver | June 20, 2025 Subscription to WBN and being a Contributor is FREE
Water vs. Fat-Soluble Compounds—Why Extraction Methods Matter
Lion’s Mane mushroom is packed with diverse compounds, but how those compounds are extracted determines how well they can work in your body. The key lies in understanding water-soluble vs. fat-soluble fractions—and why some products use water only while others use both water and alcohol (a “dual extract”).
Water-soluble compounds include:
- Polysaccharides like beta-glucans: boost immunity, balance inflammation, regulate blood sugar, and nourish gut microbes.
- Antioxidants like Superoxide Dismutase (SOD): reduce oxidative stress and support anti-aging.
- Fungal Immunomodulatory Peptides (FIPs): help with immunity, tissue repair, and even blood pressure regulation.
These compounds extract well in hot water. That’s why traditional decoction methods—like simmering mushrooms—are effective for immune support and gut health.
Fat-soluble compounds, however, require alcohol for optimal extraction. These include:
- Sterols (e.g., ergosterol): support heart health and vitamin D synthesis.
- Triterpenoids (e.g., hericenones): stimulate nerve growth factor (NGF), protect the liver, and balance hormones.
- Fatty acids: maintain brain and skin health, reduce inflammation.
- Nucleosides (like cordycepin and uridine): support energy production, adrenal balance, and cellular repair.
Because these lipophilic compounds don’t dissolve well in water, alcohol is used to create a dual extract—one that captures both the water-soluble and fat-soluble treasures hidden in the mushroom.
To summarize: water-only extracts nourish the gut and immune system, while dual extracts offer deeper cognitive, hormonal, and nerve-regenerative benefits. The method of extraction isn’t just a technicality—it’s central to what Lion’s Mane can do for you.
Reid Parr | WBN News – Vancouver Subscription to WBN and being a Contributor is FREE
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